Cytotoxic withanolides from Vietnamese ethno-medicinal plant Physalis angulata
نویسنده
چکیده
Withanolides are known as the main components of Physalis genus with broad biological activities. Using combination of various chromatographic methods, three withanolides were isolated including physagulin J (1), physagulin K (2), and physagulin N (3). Their chemical structures were determined by analysis of NMR spectra, and as well as comparison with reported literature. Compound 1 showed significant cytotoxicity toward the human lung carcinoma cell A-549 with IC50 of 8,27 ± 0,97 μM. Keywords—Physalis angulata, withanolide, physagulin J, physagulin K, physagulin N
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